Depends on the disability. I have pretty severe Rheumatoid arthritis, I have a 15, 6, and 3 year old. I love my children with my whole being, but I feel incredibly guilty that I'm unable to physically care for them the way i want too, i.e. run around, wrestle, take long walks, things like that. My pain causes me to be irritable and exhausted. I would also look into if the disability can be passed on to your children. I unfortunately didn't have any symptoms until my last one was born, and this crap can be genetic.
I know I personally could not, probably. How’s about trying out a nanny position?