It shouldn’t, my clinic is 3 hours away and we drove back home after we transferred. I just made sure to stop and walk around for blood flow. I got a positive after that transfer.
When pregnant, like further along, they don't recommend longer than 2 hours in the car without stretch breaks. If anything make sure to wiggle your legs and get blood flowing. I'd imagine it'd be fine.
I wouldn't have thought so, only thing I'd maybe consider is blood flow to your uterus so if you could stop to stretch your legs or make sure you get a walk in somewhere, I would think it would be fine x